If it’s meant to be it’s meant to be. Otherwise, fuck it.

Mark Patterson, @Expherience (via kushandwizdom)

Joke of the day.

wanderoar:

roseonabeach:

frostedsammy:

An Englishman, a Frenchman, a Spaniard and a German are all standing watching a street performer do some excellent juggling. The juggler notices that the four gentlemen have a very poor view, so he stands up on a large wooden box and calls out, “Can you all see me now?”

“Yes.”
“Oui.”
“Sí.”
“Ja.”

what

Took me about ten minutes to finally understand this

stupidest/most awesome joke ever

lmao

My baby fever been on 1000 these past few weeks…

My Dominicanita!!! The Pam to my Gina! When I got to A&M I never expected to meet one of my best friends, but life has a funny way of showing us things. It’s rare to come across people this genuine.  Happy 23rd Birthday, my love!  Wish I could’ve stayed to celebrate with you! #DasBae #SheGotALazyAssEye #ButSheStillFineTho #SheAlsoAnUndercoverLesbian #ButIdontJudgeHer ♡

My Dominicanita!!! The Pam to my Gina! When I got to A&M I never expected to meet one of my best friends, but life has a funny way of showing us things. It’s rare to come across people this genuine. Happy 23rd Birthday, my love! Wish I could’ve stayed to celebrate with you! #DasBae #SheGotALazyAssEye #ButSheStillFineTho #SheAlsoAnUndercoverLesbian #ButIdontJudgeHer ♡

Solution.

oneofthemohicans:

we did not build this wretched house they have placed us in.

we are not the architects responsible for the horrid foundation on which we have been forced to try and build. the pipes were not busted by the overflow of our greed. the holes in the wall are not a result of self-inflicted damage nor…

pretty-period:

“More girls should join boys’ teams so it could be a tradition and it wouldn’t be so special.” - 13-year-old Mo’Ne Davis, the 18th girl to play in the Little League World Series in its 68-year history, the FIRST girl to throw a Little League World Series SHUTOUT. Her fastball? 70 MILES PER HOUR. #throwlikeagirl #BlackGirlsROCK
Zoom Info
pretty-period:

“More girls should join boys’ teams so it could be a tradition and it wouldn’t be so special.” - 13-year-old Mo’Ne Davis, the 18th girl to play in the Little League World Series in its 68-year history, the FIRST girl to throw a Little League World Series SHUTOUT. Her fastball? 70 MILES PER HOUR. #throwlikeagirl #BlackGirlsROCK
Zoom Info

pretty-period:

More girls should join boys’ teams so it could be a tradition and it wouldn’t be so special.” - 13-year-old Mo’Ne Davis, the 18th girl to play in the Little League World Series in its 68-year history, the FIRST girl to throw a Little League World Series SHUTOUT. Her fastball? 70 MILES PER HOUR. #throwlikeagirl #BlackGirlsROCK

thebluelip-blondie:

ras-al-ghul-is-dead:

A silent protest in Love Park, downtown Philadelphia orchestrated by performance artists protesting the murder of Michael Brown in Ferguson. The onslaught of passerby’s  wanting to take photos with the statue exemplifies the disconnect in American society.  Simply frame out the dead body, and it doesn’t exist.  
Here are some observations by one of the artists involved in the event:
I don’t know who any of these folks are.
They were tourists I presume.
But I heard most of what everything they said. A few lines in particular stood out. There’s one guy not featured in the photos. His friends were trying to get him to join the picture but he couldn’t take his eyes off the body. 
"Something about this doesn’t feel right. I’m going to sit this one out, guys." "Com’on man… he’s already dead."
(Laughs.)
There were a billion little quips I heard today. Some broke my heart. Some restored my faith in humanity. There was an older white couple who wanted to take a picture under the statue.
The older gentleman: “Why do they have to always have to shove their politics down our throats.” Older woman: “They’re black kids, honey. They don’t have anything better to do.”
One woman even stepped over the body to get her picture. But as luck would have it the wind blew the caution tape and it got tangle around her foot. She had to stop and take the tape off. She still took her photo. 
There was a guy who yelled at us… “We need more dead like them. Yay for the white man!”
"One young guy just cried and then gave me a hug and said ‘thank you. It’s nice to know SOMEBODY sees me.’

I’m just gonna keep reblogging this because this is truly how white America works. Like people have their weddings on plantations, Blackface was and still is a major source of entertainment and the biggest movie of all time was Gone With the Wind. White America will kill Black people and then smile and laugh and enjoy their day it sickens me that we’re treated this way.
Zoom Info
thebluelip-blondie:

ras-al-ghul-is-dead:

A silent protest in Love Park, downtown Philadelphia orchestrated by performance artists protesting the murder of Michael Brown in Ferguson. The onslaught of passerby’s  wanting to take photos with the statue exemplifies the disconnect in American society.  Simply frame out the dead body, and it doesn’t exist.  
Here are some observations by one of the artists involved in the event:
I don’t know who any of these folks are.
They were tourists I presume.
But I heard most of what everything they said. A few lines in particular stood out. There’s one guy not featured in the photos. His friends were trying to get him to join the picture but he couldn’t take his eyes off the body. 
"Something about this doesn’t feel right. I’m going to sit this one out, guys." "Com’on man… he’s already dead."
(Laughs.)
There were a billion little quips I heard today. Some broke my heart. Some restored my faith in humanity. There was an older white couple who wanted to take a picture under the statue.
The older gentleman: “Why do they have to always have to shove their politics down our throats.” Older woman: “They’re black kids, honey. They don’t have anything better to do.”
One woman even stepped over the body to get her picture. But as luck would have it the wind blew the caution tape and it got tangle around her foot. She had to stop and take the tape off. She still took her photo. 
There was a guy who yelled at us… “We need more dead like them. Yay for the white man!”
"One young guy just cried and then gave me a hug and said ‘thank you. It’s nice to know SOMEBODY sees me.’

I’m just gonna keep reblogging this because this is truly how white America works. Like people have their weddings on plantations, Blackface was and still is a major source of entertainment and the biggest movie of all time was Gone With the Wind. White America will kill Black people and then smile and laugh and enjoy their day it sickens me that we’re treated this way.
Zoom Info
thebluelip-blondie:

ras-al-ghul-is-dead:

A silent protest in Love Park, downtown Philadelphia orchestrated by performance artists protesting the murder of Michael Brown in Ferguson. The onslaught of passerby’s  wanting to take photos with the statue exemplifies the disconnect in American society.  Simply frame out the dead body, and it doesn’t exist.  
Here are some observations by one of the artists involved in the event:
I don’t know who any of these folks are.
They were tourists I presume.
But I heard most of what everything they said. A few lines in particular stood out. There’s one guy not featured in the photos. His friends were trying to get him to join the picture but he couldn’t take his eyes off the body. 
"Something about this doesn’t feel right. I’m going to sit this one out, guys." "Com’on man… he’s already dead."
(Laughs.)
There were a billion little quips I heard today. Some broke my heart. Some restored my faith in humanity. There was an older white couple who wanted to take a picture under the statue.
The older gentleman: “Why do they have to always have to shove their politics down our throats.” Older woman: “They’re black kids, honey. They don’t have anything better to do.”
One woman even stepped over the body to get her picture. But as luck would have it the wind blew the caution tape and it got tangle around her foot. She had to stop and take the tape off. She still took her photo. 
There was a guy who yelled at us… “We need more dead like them. Yay for the white man!”
"One young guy just cried and then gave me a hug and said ‘thank you. It’s nice to know SOMEBODY sees me.’

I’m just gonna keep reblogging this because this is truly how white America works. Like people have their weddings on plantations, Blackface was and still is a major source of entertainment and the biggest movie of all time was Gone With the Wind. White America will kill Black people and then smile and laugh and enjoy their day it sickens me that we’re treated this way.
Zoom Info
thebluelip-blondie:

ras-al-ghul-is-dead:

A silent protest in Love Park, downtown Philadelphia orchestrated by performance artists protesting the murder of Michael Brown in Ferguson. The onslaught of passerby’s  wanting to take photos with the statue exemplifies the disconnect in American society.  Simply frame out the dead body, and it doesn’t exist.  
Here are some observations by one of the artists involved in the event:
I don’t know who any of these folks are.
They were tourists I presume.
But I heard most of what everything they said. A few lines in particular stood out. There’s one guy not featured in the photos. His friends were trying to get him to join the picture but he couldn’t take his eyes off the body. 
"Something about this doesn’t feel right. I’m going to sit this one out, guys." "Com’on man… he’s already dead."
(Laughs.)
There were a billion little quips I heard today. Some broke my heart. Some restored my faith in humanity. There was an older white couple who wanted to take a picture under the statue.
The older gentleman: “Why do they have to always have to shove their politics down our throats.” Older woman: “They’re black kids, honey. They don’t have anything better to do.”
One woman even stepped over the body to get her picture. But as luck would have it the wind blew the caution tape and it got tangle around her foot. She had to stop and take the tape off. She still took her photo. 
There was a guy who yelled at us… “We need more dead like them. Yay for the white man!”
"One young guy just cried and then gave me a hug and said ‘thank you. It’s nice to know SOMEBODY sees me.’

I’m just gonna keep reblogging this because this is truly how white America works. Like people have their weddings on plantations, Blackface was and still is a major source of entertainment and the biggest movie of all time was Gone With the Wind. White America will kill Black people and then smile and laugh and enjoy their day it sickens me that we’re treated this way.
Zoom Info
thebluelip-blondie:

ras-al-ghul-is-dead:

A silent protest in Love Park, downtown Philadelphia orchestrated by performance artists protesting the murder of Michael Brown in Ferguson. The onslaught of passerby’s  wanting to take photos with the statue exemplifies the disconnect in American society.  Simply frame out the dead body, and it doesn’t exist.  
Here are some observations by one of the artists involved in the event:
I don’t know who any of these folks are.
They were tourists I presume.
But I heard most of what everything they said. A few lines in particular stood out. There’s one guy not featured in the photos. His friends were trying to get him to join the picture but he couldn’t take his eyes off the body. 
"Something about this doesn’t feel right. I’m going to sit this one out, guys." "Com’on man… he’s already dead."
(Laughs.)
There were a billion little quips I heard today. Some broke my heart. Some restored my faith in humanity. There was an older white couple who wanted to take a picture under the statue.
The older gentleman: “Why do they have to always have to shove their politics down our throats.” Older woman: “They’re black kids, honey. They don’t have anything better to do.”
One woman even stepped over the body to get her picture. But as luck would have it the wind blew the caution tape and it got tangle around her foot. She had to stop and take the tape off. She still took her photo. 
There was a guy who yelled at us… “We need more dead like them. Yay for the white man!”
"One young guy just cried and then gave me a hug and said ‘thank you. It’s nice to know SOMEBODY sees me.’

I’m just gonna keep reblogging this because this is truly how white America works. Like people have their weddings on plantations, Blackface was and still is a major source of entertainment and the biggest movie of all time was Gone With the Wind. White America will kill Black people and then smile and laugh and enjoy their day it sickens me that we’re treated this way.
Zoom Info
thebluelip-blondie:

ras-al-ghul-is-dead:

A silent protest in Love Park, downtown Philadelphia orchestrated by performance artists protesting the murder of Michael Brown in Ferguson. The onslaught of passerby’s  wanting to take photos with the statue exemplifies the disconnect in American society.  Simply frame out the dead body, and it doesn’t exist.  
Here are some observations by one of the artists involved in the event:
I don’t know who any of these folks are.
They were tourists I presume.
But I heard most of what everything they said. A few lines in particular stood out. There’s one guy not featured in the photos. His friends were trying to get him to join the picture but he couldn’t take his eyes off the body. 
"Something about this doesn’t feel right. I’m going to sit this one out, guys." "Com’on man… he’s already dead."
(Laughs.)
There were a billion little quips I heard today. Some broke my heart. Some restored my faith in humanity. There was an older white couple who wanted to take a picture under the statue.
The older gentleman: “Why do they have to always have to shove their politics down our throats.” Older woman: “They’re black kids, honey. They don’t have anything better to do.”
One woman even stepped over the body to get her picture. But as luck would have it the wind blew the caution tape and it got tangle around her foot. She had to stop and take the tape off. She still took her photo. 
There was a guy who yelled at us… “We need more dead like them. Yay for the white man!”
"One young guy just cried and then gave me a hug and said ‘thank you. It’s nice to know SOMEBODY sees me.’

I’m just gonna keep reblogging this because this is truly how white America works. Like people have their weddings on plantations, Blackface was and still is a major source of entertainment and the biggest movie of all time was Gone With the Wind. White America will kill Black people and then smile and laugh and enjoy their day it sickens me that we’re treated this way.
Zoom Info
thebluelip-blondie:

ras-al-ghul-is-dead:

A silent protest in Love Park, downtown Philadelphia orchestrated by performance artists protesting the murder of Michael Brown in Ferguson. The onslaught of passerby’s  wanting to take photos with the statue exemplifies the disconnect in American society.  Simply frame out the dead body, and it doesn’t exist.  
Here are some observations by one of the artists involved in the event:
I don’t know who any of these folks are.
They were tourists I presume.
But I heard most of what everything they said. A few lines in particular stood out. There’s one guy not featured in the photos. His friends were trying to get him to join the picture but he couldn’t take his eyes off the body. 
"Something about this doesn’t feel right. I’m going to sit this one out, guys." "Com’on man… he’s already dead."
(Laughs.)
There were a billion little quips I heard today. Some broke my heart. Some restored my faith in humanity. There was an older white couple who wanted to take a picture under the statue.
The older gentleman: “Why do they have to always have to shove their politics down our throats.” Older woman: “They’re black kids, honey. They don’t have anything better to do.”
One woman even stepped over the body to get her picture. But as luck would have it the wind blew the caution tape and it got tangle around her foot. She had to stop and take the tape off. She still took her photo. 
There was a guy who yelled at us… “We need more dead like them. Yay for the white man!”
"One young guy just cried and then gave me a hug and said ‘thank you. It’s nice to know SOMEBODY sees me.’

I’m just gonna keep reblogging this because this is truly how white America works. Like people have their weddings on plantations, Blackface was and still is a major source of entertainment and the biggest movie of all time was Gone With the Wind. White America will kill Black people and then smile and laugh and enjoy their day it sickens me that we’re treated this way.
Zoom Info
thebluelip-blondie:

ras-al-ghul-is-dead:

A silent protest in Love Park, downtown Philadelphia orchestrated by performance artists protesting the murder of Michael Brown in Ferguson. The onslaught of passerby’s  wanting to take photos with the statue exemplifies the disconnect in American society.  Simply frame out the dead body, and it doesn’t exist.  
Here are some observations by one of the artists involved in the event:
I don’t know who any of these folks are.
They were tourists I presume.
But I heard most of what everything they said. A few lines in particular stood out. There’s one guy not featured in the photos. His friends were trying to get him to join the picture but he couldn’t take his eyes off the body. 
"Something about this doesn’t feel right. I’m going to sit this one out, guys." "Com’on man… he’s already dead."
(Laughs.)
There were a billion little quips I heard today. Some broke my heart. Some restored my faith in humanity. There was an older white couple who wanted to take a picture under the statue.
The older gentleman: “Why do they have to always have to shove their politics down our throats.” Older woman: “They’re black kids, honey. They don’t have anything better to do.”
One woman even stepped over the body to get her picture. But as luck would have it the wind blew the caution tape and it got tangle around her foot. She had to stop and take the tape off. She still took her photo. 
There was a guy who yelled at us… “We need more dead like them. Yay for the white man!”
"One young guy just cried and then gave me a hug and said ‘thank you. It’s nice to know SOMEBODY sees me.’

I’m just gonna keep reblogging this because this is truly how white America works. Like people have their weddings on plantations, Blackface was and still is a major source of entertainment and the biggest movie of all time was Gone With the Wind. White America will kill Black people and then smile and laugh and enjoy their day it sickens me that we’re treated this way.
Zoom Info

thebluelip-blondie:

ras-al-ghul-is-dead:

A silent protest in Love Park, downtown Philadelphia orchestrated by performance artists protesting the murder of Michael Brown in Ferguson. The onslaught of passerby’s  wanting to take photos with the statue exemplifies the disconnect in American society.  Simply frame out the dead body, and it doesn’t exist.  

Here are some observations by one of the artists involved in the event:

I don’t know who any of these folks are.

They were tourists I presume.

But I heard most of what everything they said. A few lines in particular stood out. There’s one guy not featured in the photos. His friends were trying to get him to join the picture but he couldn’t take his eyes off the body.

"Something about this doesn’t feel right. I’m going to sit this one out, guys." "Com’on man… he’s already dead."

(Laughs.)

There were a billion little quips I heard today. Some broke my heart. Some restored my faith in humanity. There was an older white couple who wanted to take a picture under the statue.

The older gentleman: “Why do they have to always have to shove their politics down our throats.” Older woman: “They’re black kids, honey. They don’t have anything better to do.”

One woman even stepped over the body to get her picture. But as luck would have it the wind blew the caution tape and it got tangle around her foot. She had to stop and take the tape off. She still took her photo.

There was a guy who yelled at us… “We need more dead like them. Yay for the white man!”

"One young guy just cried and then gave me a hug and said ‘thank you. It’s nice to know SOMEBODY sees me.’

I’m just gonna keep reblogging this because this is truly how white America works. Like people have their weddings on plantations, Blackface was and still is a major source of entertainment and the biggest movie of all time was Gone With the Wind. White America will kill Black people and then smile and laugh and enjoy their day it sickens me that we’re treated this way.

mindblowingscience:

Epigenetic Breakthrough Bolsters Understanding of Alzheimer’s Disease

A team led by researchers at the University of Exeter Medical School and King’s College London has uncovered some of the strongest evidence yet that epigenetic changes in the brain play a role in Alzheimer’s disease.
Epigenetic changes affect the expression or activity of genes without changing the underlying DNA sequence and are believed to be one mechanism by which the environment can interact with the genome. Importantly, epigenetic changes are potentially reversible and may therefore provide targets for the development of new therapies.
Globally, more than 26 million people are currently affected by Alzheimer’s Disease. As this number grows in line with an increasingly aging population, the need to identify new disease mechanisms is more important than ever. Post-mortem examinations have revealed much about how Alzheimer’s damages the brain, with some regions, such as the entorhinal cortex, being particularly susceptible, while others, such as the cerebellum, remain virtually unscathed. However, little is yet known about how and why the disease develops in specific brain regions.
The current study found that chemical modifications to DNA within the ANK1 gene are strongly associated with measures of neuropathology in the brain. The study, published inNature Neuroscience, found that people with more Alzheimer’s disease-related neuropathology in their brains had higher levels of DNA modifications within the ANK1 gene. The finding was particularly strong in the entorhinal cortex, and also detected in other cortical regions affected by the disease. In contrast, no significant changes were observed in less affected brain regions or blood.

Continue Reading.

mindblowingscience:

Epigenetic Breakthrough Bolsters Understanding of Alzheimer’s Disease

A team led by researchers at the University of Exeter Medical School and King’s College London has uncovered some of the strongest evidence yet that epigenetic changes in the brain play a role in Alzheimer’s disease.

Epigenetic changes affect the expression or activity of genes without changing the underlying DNA sequence and are believed to be one mechanism by which the environment can interact with the genome. Importantly, epigenetic changes are potentially reversible and may therefore provide targets for the development of new therapies.

Globally, more than 26 million people are currently affected by Alzheimer’s Disease. As this number grows in line with an increasingly aging population, the need to identify new disease mechanisms is more important than ever. Post-mortem examinations have revealed much about how Alzheimer’s damages the brain, with some regions, such as the entorhinal cortex, being particularly susceptible, while others, such as the cerebellum, remain virtually unscathed. However, little is yet known about how and why the disease develops in specific brain regions.

The current study found that chemical modifications to DNA within the ANK1 gene are strongly associated with measures of neuropathology in the brain. The study, published inNature Neuroscience, found that people with more Alzheimer’s disease-related neuropathology in their brains had higher levels of DNA modifications within the ANK1 gene. The finding was particularly strong in the entorhinal cortex, and also detected in other cortical regions affected by the disease. In contrast, no significant changes were observed in less affected brain regions or blood.

Continue Reading.